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Updated: Feb 15, 2026

Purification of Endogenous Drosophila Transient Receptor Potential Channels
Published on: December 28, 2021
[Research advances in the association between transient receptor potential cation channel 6 and kidney disease]
1Graduate School of Youjiang University for Nationalities, Baise, Gangxi 533000, China. 454785063@qq.com.
Abstract:
Transient receptor potential cation channel 6 (TRPC6) is a member of the transient receptor superfamily encoded by the TRPC6 gene and is widely expressed in tissues and organs of the human body, especially in the glomerular podocytes. TRPC6 interacts with various slit diaphragm (SD) proteins including podocin, nephrin, ACTN4, and CD2AP to maintain the normal structure and function of glomerular podocytes. Foot process fusion caused by podocyte damage due to various factors is the most important morphological change in kidney disease. This article reviews the biological function of TRPC6 and its effect on kidney disease.
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