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Updated: Feb 15, 2026

Functional Assessment of BRCA1 variants using CRISPR-Mediated Base Editors
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White Blood Cell BRCA1 Promoter Methylation Status and Ovarian Cancer Risk

Per E Lønning1, Elisabet O Berge1, Merete Bjørnslett2

  • 1University of Bergen and Haukeland University Hospital, Bergen, Norway (P.E.L., E.O.B., L.M., R.C., S.B., C.E., L.B., H.B.S., S.K.).

Annals of Internal Medicine
|January 17, 2018
PubMed
Summary

Normal tissue BRCA1 promoter methylation is linked to increased ovarian cancer risk, particularly high-grade serous ovarian cancer (HGSOC). This finding suggests a potential biomarker for HGSOC development.

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