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Updated: Feb 15, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
[Prevention of cardiovascular diseases]
J H Prochaska1,2,3,4, N Arnold5,6, C Jünger5,7,6
1Präventive Kardiologie und Medizinische Prävention, Zentrum für Kardiologie, Universitätsmedizin der Johannes-Gutenberg-Universität Mainz, Langenbeckstr. 1, 55131, Mainz, Deutschland. juergen.prochaska@unimedizin-mainz.de.
Abstract:
The incidence of cardiovascular diseases can be reduced by the early detection and targeted treatment of risk factors and subclinical forms of the disease. Primary prevention provides several opportunities for successful interventions. In addition to a drug-based therapy, especially life style-modifying measures, such as physical activity, normalization of body weight, consistent nicotine abstinence and the consideration of psychosocial aspects represent core components of prevention programs. Healthcare data indicate that risk factors still often remain undetected and that the full potential of risk factor management has not yet been fully exploited at a population level. Especially motivation of patients and adherence to therapy represent key elements of successful prevention efforts.
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