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Updated: Feb 15, 2026
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Adipocyte-Specific ATAC-Seq with Adipose Tissues Using Fluorescence-Activated Nucleus Sorting
Published on: March 17, 2023
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Specific Modulation of Vertebral Marrow Adipose Tissue by Physical Activity
Daniel L Belavy1, Matthew J Quittner1, Nicola D Ridgers1
1Deakin University, Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Geelong, Australia.
Summary
Regular, high-impact exercise like long-distance running is associated with lower marrow adipose tissue (MAT), potentially reversing age-related bone marrow changes. This finding suggests exercise is a modifiable factor for bone health and metabolism.
Area of Science:
- Bone and Mineral Metabolism
- Exercise Physiology
- Radiology
Background:
- Marrow adipose tissue (MAT) increases with age, affecting bone, hemopoiesis, and metabolism.
- Understanding factors influencing MAT is crucial for bone health and metabolic regulation.
Purpose of the Study:
- To investigate the association between different types and volumes of exercise and vertebral marrow fat fraction (VFF) in healthy young adults.
- To determine if exercise can influence age-related changes in bone marrow composition.
Main Methods:
- 101 healthy adults (25-35 years) with varied exercise histories were studied.
- Vertebral marrow fat fraction (VFF) was measured using MRI.
- Exercise volume (km/wk) and type (running, cycling, impact) were recorded and correlated with VFF.
Main Results:
- Long-distance runners (67 km/wk) had significantly lower lumbar VFF compared to non-exercising controls.
- Habitual joggers (28 km/wk) showed reduced VFF at specific vertebrae.
- High-volume cycling did not affect VFF, while high-impact activities correlated with lower VFF.
Conclusions:
- Specific exercise types and volumes, particularly high-impact running, are associated with reduced MAT.
- Exercise may modify age-related adipose marrow conversion, offering an 8-year younger phenotype in runners.
- Exercise represents a potentially modifiable risk factor for bone metabolism and hemopoietic disorders.
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