Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

32.5K
Overview
32.5K
Tumor Immunotherapy01:27

Tumor Immunotherapy

2.0K
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
2.0K
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

18
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
18
Allergic Drug Reactions01:27

Allergic Drug Reactions

1.5K
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
1.5K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

16
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
16
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comorbidities as a Personalized Target in Patients with Severe Asthma Treated with Dupilumab.

Journal of personalized medicine·2025
Same author

The immune response to SARS-CoV-2 in COVID-19 as a recall response susceptible to immune imprinting: A prospective cohort study.

Clinical immunology (Orlando, Fla.)·2025
Same author

Changes in CD4<sup>+</sup> T cells subsets in patients with alcohol-related cirrhosis.

Clinical and experimental medicine·2025
Same author

Prognostic Factors in Severe Eosinophilic Asthma in a Pediatric Population: A Prospective Cohort Study in Spain.

Journal of clinical medicine·2024
Same author

Prognostic Significance of PD-L1 Expression on Circulating Myeloid-Derived Suppressor Cells in NSCLC Patients Treated with Anti-PD-1/PD-L1 Checkpoint Inhibitors.

International journal of molecular sciences·2024
Same author

Peripheral blood T-cell modulation by omalizumab in chronic urticaria patients.

Frontiers in immunology·2024

Related Experiment Video

Updated: Feb 15, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.1K

Immunotheraphy in Allergic Diseases.

Albert Roger1, Maria Basagana1, Aina Teniente-Serra2,3

  • 1Allergy Section, University Hospital Germans Trias i Pujol, Badalona, Spain.

Current Pharmaceutical Design
|January 17, 2018
PubMed
Summary

Allergic diseases affect over 30% of the global population, particularly young individuals. Allergen-specific immunotherapy offers disease modification for IgE-mediated allergies, with new strategies under development.

Keywords:
IgEImmunotherapyadjuvantsallergyantigenstolerance.

More Related Videos

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.7K
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

16.0K

Related Experiment Videos

Last Updated: Feb 15, 2026

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.1K
Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
08:40

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy

Published on: August 1, 2013

18.7K
Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy
06:51

Manufacturing Chimeric Antigen Receptor CAR T Cells for Adoptive Immunotherapy

Published on: December 17, 2019

16.0K

Area of Science:

  • Immunology
  • Allergology
  • Clinical Medicine

Background:

  • Global prevalence of allergic diseases is rising, impacting over 30% of the population, with a notable increase in young people.
  • Accurate allergy diagnosis, based on symptom history and allergen-specific IgE detection, is crucial for effective treatment.
  • Allergen-specific immunotherapy (AIT) is the sole disease-modifying therapy for IgE-mediated allergic conditions.

Purpose of the Study:

  • To review current and emerging allergen-specific immunotherapies.
  • To analyze AIT based on administration routes, antigen types, and adjuvants.
  • To discuss the specific challenges and approaches for food allergy.

Main Methods:

  • Review of existing literature on allergen-specific immunotherapies.
  • Analysis of new therapeutic strategies, including novel allergens and administration routes.
  • Examination of the role of adjuvants in amplifying immune tolerance.

Main Results:

  • Several new therapeutic strategies for allergy are under development or in clinical trials.
  • Novel allergen preparations and administration routes are being explored to improve AIT efficacy.
  • Adjuvants show potential in enhancing immune responses towards antigen tolerance.

Conclusions:

  • Allergen-specific immunotherapy remains a key treatment for IgE-mediated allergies.
  • Advancements in AIT, including new antigens and adjuvants, offer promising therapeutic options.
  • Further research is needed, especially for complex cases like food allergies.