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Updated: Feb 1, 2026

Reconstruct Human Retinoblastoma In Vitro
Published on: October 11, 2022
Incidental neuroblastoma with bilateral retinoblastoma: what are the chances?
Kelsey Roelofs1, Furqan Shaikh2, William Astle3
1a Department of Ophthalmology and Visual Sciences , University of Alberta , Calgary, AB , Canada.
Abstract:
A child with bilateral familial retinoblastoma underwent staging MRI brain and orbit which identified subtle leptomeningeal enhancement, thus prompting an MRI whole body, which revealed a retroperitoneal mass, confirmed on laparoscopic biopsy to be neuroblastoma. This is the first reported case of these two rare embryonal non-central nervous system tumors occurring concurrently. The cause of this concurrence is unknown despite their pathogenic similarities with a chance of 4 cases per 10 billion children aged 1-4 years. Incidental neuroblastomas in infants can regress spontaneously but this child underwent systemic chemotherapy for his retinoblastoma that may have caused regression of the neuroblastoma.
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