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Updated: Feb 15, 2026
A Protocol for Constructing a Rat Wound Model of Type 1 Diabetes
Published on: February 17, 2023
sICAM-1, sVCAM-1 and sE-Selectin Levels in Type 1 Diabetes
Anwar Fathollahi1, Ahmad Massoud1, Ali Akbar Amirzargar1,2
1a Department of Immunology, School of Medicine , Tehran University of Medical Sciences , Tehran , Iran.
Background/Objective:
This study was performed to compare soluble levels of adhesion molecules between diabetic patients and controls and to assess their possible association with long-term complications of type 1 diabetes (T1D).
Methods:
Forty-eight patients with T1D and 39 healthy controls were enrolled in this study. The plasma level of adhesion molecules was measured by sandwich enzyme-linked immunosorbent assay technique.
Results:
Higher sVCAM 1 (soluble vascular cell adhesion molecule 1) levels correlated with older age of onset of T1D. The plasma level of sICAM 1 (soluble intercellular adhesion molecule 1) was significantly increased, while sE selectin was significantly decreased in patients with T1D, compared to controls. There was no significant relationship between these plasma-level variations and the long-term complications of T1D.
Conclusion:
Although plasma levels of cell adhesion molecules are different in T1D patients and healthy controls, they might not be good candidate markers for prognosis of disease.
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