[Allogenic interactions in immunopathology]

Allogeneic interactions associated with experimental graft-versus-host reaction are sometimes responsible for the development of autoantibodies, immune complex lesions and malignant lymphocytic proliferation. Hypergammaglobulinaemia reflects the activation of B cells, and T cell-associated responses are deeply depressed. Some of these abnormalities are also found in chimera mice following injection of semi-allogeneic cells. The place of allogeneic interactions in human pathology has not yet been determined, but they might intervene in the pathogenesis of some autoimmune and lymphoproliferative diseases and in the acquired immune deficiency syndrome.