Related Experiment Video

Updated: Feb 15, 2026

A Mouse Model of Lumbar Spine Instability
05:28

A Mouse Model of Lumbar Spine Instability

Published on: April 23, 2021

9.1K

DISC: Describing Infections of the Spine treated with Ceftaroline

Richard R Watkins1, George Yendewa2, Steven D Burdette3

  • 1Division of Infectious Diseases, Cleveland Clinic Akron General, Akron, OH, USA; Department of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.

Journal of Global Antimicrobial Resistance
|January 17, 2018
PubMed
Abstract

Insights

Ceftaroline is a safe and effective treatment for spine infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). This study found similar clinical success rates compared to other antibiotics.

Area of Science:

  • Infectious Diseases
  • Pharmacology
  • Orthopedic Surgery

Background:

  • Spine infections cause significant morbidity and healthcare costs.
  • Evidence for ceftaroline, an advanced cephalosporin active against MRSA, in spine infections is limited.

Purpose of the Study:

  • To evaluate the safety and efficacy of ceftaroline for treating spine infections.
  • To compare ceftaroline treatment outcomes against a comparator antibiotic group.

Main Methods:

  • A multicentre, retrospective cohort study (Describing Infections of the Spine treated with Ceftaroline - DISC).
  • Included patients aged ≥18 years with spine infections treated for ≥28 days with ceftaroline or a comparator antibiotic.

Main Results:

  • 37 patients in each group; MRSA was the most common pathogen.
  • Ceftaroline showed similar clinical success to comparator antibiotics (aOR=1.49; P=0.711).
  • Higher discharge to extended-care/rehab for ceftaroline group (81% vs. 54%; P=0.024); rare side effects.

Conclusions:

  • Ceftaroline is a safe and effective option for spine infections, including MRSA.
  • Further research may explore optimal use in specific patient populations.
Keywords:
CeftarolineDiscitisEpidural abscessMRSAVertebral osteomyelitis

More Related Videos

Author Spotlight: Unveiling the Potential of TUBE Technique in Spinal Surgery06:26

Author Spotlight: Unveiling the Potential of TUBE Technique in Spinal Surgery

Published on: November 17, 2023

2.3K
An In Vitro Organ Culture Model of the Murine Intervertebral Disc08:03

An In Vitro Organ Culture Model of the Murine Intervertebral Disc

Published on: April 11, 2017

10.3K

Related Concept Videos

Design Example: Calculating Safe Diameter for Wind-Exposed Disc01:17

Design Example: Calculating Safe Diameter for Wind-Exposed Disc

Assessing safety in wind-exposed installations is crucial to preventing potential failures. This example explores the calculation and design adjustments needed to mount a circular disc on a building facade, where wind forces are a primary concern. A 4-meter diameter disc was initially designed as an aesthetic feature facing winds at a velocity of 25 meters per second, with an air density of 1.25 kilograms per cubic meter. Given these conditions, the drag force on the disc was determined using...
365
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
12.8K
Stages of Infection01:26

Stages of Infection

Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
65.6K
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...
1.4K
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
9.8K
Sexually Transmitted Infections01:26

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
1.2K