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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Recording Horizontal Saccade Performances Accurately in Neurological Patients Using Electro-oculogram
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[Neurology].

Isabelle Chopard1, David Benninger1, Jean-François Demonet1

  • 1Service de neurologie, Département des neurosciences cliniques, CHUV, 1011 Lausanne.

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|January 17, 2018
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Summary
This summary is machine-generated.

New therapeutic strategies are emerging for neurological disorders. Ocrelizumab for multiple sclerosis, eculizumab for myasthenia gravis, and patisiran for amyloidosis show promise. Non-pharmacological migraine treatments and revised dementia criteria are also noted.

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Area of Science:

  • Neurology
  • Immunology
  • Genetics
  • Pharmacology

Background:

  • Advances in treating neurological conditions are rapidly evolving.
  • Targeted therapies and revised diagnostic criteria are improving patient outcomes.
  • Multiple sclerosis, myasthenia gravis, and amyloidosis represent significant challenges in neuro-immunology and genetics.

Purpose of the Study:

  • To review recent advancements in the treatment of multiple sclerosis, myasthenia gravis, and transthyretin familial amyloidosis.
  • To highlight emerging non-pharmacological approaches for headache and migraine management.
  • To note revisions in diagnostic criteria for Lewy body dementia and the safety of generic lamotrigine.

Main Methods:

  • Review of approved therapies including monoclonal antibodies and gene therapy.
  • Discussion of non-pharmacological interventions for migraines.
  • Summary of updated diagnostic criteria for Lewy body dementia.
  • Analysis of safety data for generic lamotrigine.

Main Results:

  • Ocrelizumab (anti-CD20) is approved for multiple sclerosis.
  • Eculizumab (Soliris) is approved for severe generalized myasthenia gravis.
  • Patisiran gene therapy shows positive results in transthyretin familial amyloidosis.
  • Non-pharmacological migraine treatments show promise.
  • Revised criteria for Lewy body dementia are available.
  • Generic lamotrigine use is safe regarding seizures and adverse effects.

Conclusions:

  • Significant progress has been made in targeted therapies for neurological and neuromuscular disorders.
  • Diverse treatment modalities, from immunotherapy to gene therapy and non-pharmacological approaches, are expanding therapeutic options.
  • Updated diagnostic criteria and safety profiles of generic medications contribute to better patient management.