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Intranasal Delivery of Therapeutic Stem Cells to Glioblastoma in a Mouse Model
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Glioblastoma under Siege: An Overview of Current Therapeutic Strategies

Mayra Paolillo1, Cinzia Boselli2, Sergio Schinelli3

  • 1Department of Drug Sciences, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy. mayra.paolillo@unipv.it.

Brain Sciences
|January 17, 2018
PubMed

Insights

Glioblastoma remains a deadly cancer with limited treatment options. This review explores new molecular targets and advanced therapies, including immunotherapy and novel drug delivery systems, to improve patient outcomes.

Area of Science:

  • Neuro-oncology
  • Genomics and Transcriptomics
  • Cancer Therapeutics

Background:

  • Glioblastoma is a highly lethal and difficult-to-treat human brain tumor.
  • Current treatments like surgery, radiotherapy, and temozolomide offer limited efficacy.
  • There is a critical need for novel therapeutic strategies and improved models for glioblastoma research.

Purpose of the Study:

  • To review the current molecular classification of glioblastoma based on genomic and transcriptomic data.
  • To describe the current clinical practice and ongoing clinical trials for glioblastoma therapy.
  • To discuss emerging therapeutic approaches, including novel pharmaceutical formulations and immunotherapy.

Main Methods:

  • Literature review of current glioblastoma research and clinical practice.
  • Analysis of genomic and transcriptomic data for molecular classification.
  • Discussion of novel therapeutic strategies and formulations.

Main Results:

  • Glioblastoma classification is evolving with genomic and transcriptomic insights.
  • Current therapies have limited success, highlighting the need for new approaches.
  • Emerging treatments include nanoparticles, viral vectors, monoclonal antibodies, vaccines, and checkpoint inhibitors.

Conclusions:

  • Refined molecular classification is crucial for targeted glioblastoma therapy.
  • Novel pharmaceutical formulations and immunotherapy represent promising avenues for treatment.
  • Continued research into molecular pathways and advanced therapies is essential to improve glioblastoma prognosis.
Keywords:
alkylating agentsimmunotherapymonoclonal antibodiesnanoparticles

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