Two Novel Proline-Containing Catechin Glucoside from Water-Soluble Extract of Codonopsis pilosula
Fu-Ying Qin1,2,3, Li-Zhi Cheng4, Yong-Ming Yan4
1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China. qinfuying@mail.kib.ac.cn.
Abstract:
Choushenflavonoids A (1) and B (2), two unusual proline-containing catechin glucosides, were isolated from the roots of Codonopsis pilosula cultivated in a high-altitude location of Yunnan province. Their structures were determined by spectroscopic data and chemical methods. Specifically, the absolute configuration of glucose residue in 1 and 2 was assigned by acid hydrolysis followed by derivatization and gas chromatography (GC) analysis. In addition, biological evaluation of 1 and 2 against Sirtuin 1 (SIRT1) was carried out.
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