Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems01:19

Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems

766
Phase I biotransformation reactions are integral to drug metabolism, predominantly involving oxidative, reductive, and hydrolytic transformations. Chief among these are oxidative reactions, which enhance the hydrophilicity of xenobiotics and introduce polar functional groups to facilitate their elimination from the body.
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
766
Basicity of Aliphatic Amines01:21

Basicity of Aliphatic Amines

6.9K
Amines can behave as Brønsted–Lowry bases by accepting a proton from the acid to form corresponding conjugate acids. Due to a lone pair of nonbonding electrons, aliphatic amines can also act as Lewis bases by forming a covalent bond with an electrophile.
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
6.9K
Oxidation Numbers03:14

Oxidation Numbers

43.3K
In redox reactions, the transfer of electrons occurs between reacting species. Electron transfer is described by a hypothetical number called the oxidation number (or oxidation state). It represents the effective charge of an atom or element, which is assigned using a set of rules.
43.3K
Pyruvate Oxidation01:15

Pyruvate Oxidation

169.6K
After glycolysis, the charged pyruvate molecules enter the mitochondria via active transport and undergo three enzymatic reactions. These reactions ensure that pyruvate can enter the next metabolic pathway so that energy stored in the pyruvate molecules can be harnessed by the cells.
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
169.6K
Oxidation-Reduction Reactions03:11

Oxidation-Reduction Reactions

75.9K
Oxidation–Reduction Reactions
75.9K
What is Natural Selection?01:32

What is Natural Selection?

129.9K
Natural selection is an evolutionary process in which individuals with survival-promoting traits reproduce at higher rates. These favorable traits become more common within a population or species. Naturally selected traits initially arise via random genetic mutations. In order for selection to occur, there must be variation within a population, the trait controlling the variation must be heritable, and there must be an evolutionary advantage for variation in the trait.
129.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Installing Axial Chirality by Atroposelective C(sp<sup>3</sup>)-H Bond Oxidation.

Journal of the American Chemical Society·2026
Same author

Desymmetrization of Malonic Monoesters and Malonic Acids via Enantioselective Catalytic C(sp<sup>3</sup>)─H Oxidation.

Angewandte Chemie (International ed. in English)·2026
Same author

Chemoselective Oxygenation at C(<i>sp</i><sup>3</sup>)-H over C═C Bonds Guided by Polarity Enhancement.

The Journal of organic chemistry·2026
Same author

Transient Induction of Chirality from an Activated Carboxylic Acid to a Zinc Complex.

Angewandte Chemie (International ed. in English)·2025
Same author

Catalytic Dioxygen Activation Using a Diketopiperazine and a Manganese Catalyst for Selective C(sp<sup>3</sup>)-H Oxidation.

JACS Au·2025
Same author

Iron-Catalyzed Intermolecular N-H Insertion Using Acceptor-Acceptor Carbenes Derived from Iodonium Ylides.

Organic letters·2025

Related Experiment Video

Updated: Feb 15, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

19.3K

Controlling Selectivity in Aliphatic C-H Oxidation through Supramolecular Recognition.

Diego Vidal1, Giorgio Olivo1, Miquel Costas1

  • 1Institut de Química Computacional i Catàlisi (IQCC) and Departament de Química, Universitat de Girona, Campus de Montilivi, 17071, Girona, Spain.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|January 17, 2018
PubMed
Summary

Molecular catalysts and supramolecular receptors mimic enzymes to control site selectivity in aliphatic C-H oxidation. This recognition-driven approach enables functionalization of previously inaccessible C-H bonds.

Keywords:
C−H oxidationcatalysismolecular recognitionselectivitysupramolecular chemistry

More Related Videos

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

10.5K
Generating Strictly Controlled Stimuli for Figure Recognition Experiments
05:39

Generating Strictly Controlled Stimuli for Figure Recognition Experiments

Published on: March 18, 2019

5.6K

Related Experiment Videos

Last Updated: Feb 15, 2026

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
16:24

Controlling the Size, Shape and Stability of Supramolecular Polymers in Water

Published on: August 2, 2012

19.3K
Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

10.5K
Generating Strictly Controlled Stimuli for Figure Recognition Experiments
05:39

Generating Strictly Controlled Stimuli for Figure Recognition Experiments

Published on: March 18, 2019

5.6K

Area of Science:

  • Organic Chemistry
  • Catalysis
  • Supramolecular Chemistry

Background:

  • Aliphatic C-H oxidation is a key method for functionalizing hydrocarbons.
  • Controlling site selectivity in C-H oxidation is challenging due to multiple reactive sites.
  • Enzymes achieve selectivity through precise substrate orientation via molecular interactions.

Purpose of the Study:

  • To review recognition-driven C-H oxidation reactions.
  • To highlight design principles for achieving site selectivity using molecular catalysts and supramolecular receptors.
  • To explore strategies for mimicking enzymatic control in synthetic C-H functionalization.

Main Methods:

  • Review of literature on recognition-driven C-H oxidation.
  • Analysis of substrate-receptor adduct geometry in dictating selectivity.
  • Discussion of catalyst and receptor design for targeted C-H bond activation.

Main Results:

  • Demonstration that supramolecular receptors can direct molecular catalysts to specific C-H bonds.
  • Identification of C-H bonds not typically accessible via conventional methods that can be functionalized.
  • Successful replication of enzyme-like selectivity through designed molecular assemblies.

Conclusions:

  • Combining molecular catalysts with supramolecular receptors offers a powerful strategy for selective C-H oxidation.
  • This approach overcomes limitations of intrinsic reactivity and conventional methodologies.
  • The principles discussed provide a roadmap for designing novel recognition-driven oxidation systems.