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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Retinal oximetry is affected in multiple sclerosis.

Anna Bryndis Einarsdottir1,2, Olof Birna Olafsdottir3,4, Haukur Hjaltason1,4

  • 1Department of Neurology, Landspitali - National University Hospital, Reykjavik, Iceland.

Acta Ophthalmologica
|January 17, 2018
PubMed
Summary
This summary is machine-generated.

Retinal oximetry revealed increased venular oxygen saturation in multiple sclerosis (MS) patients compared to healthy individuals. This finding may suggest reduced oxygen uptake and serve as a potential biomarker for MS progression.

Keywords:
biomarkerblood vesselsmultiple sclerosisoxygenretinaretinal oximetry

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Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Diagnostics

Background:

  • Retinal abnormalities are documented in multiple sclerosis (MS).
  • Retinal oximetry has shown potential in detecting metabolic changes in neurodegenerative diseases like Alzheimer's.
  • Investigating retinal oxygen metabolism may offer new insights into MS pathophysiology.

Purpose of the Study:

  • To compare retinal blood oxygen saturation levels between individuals with MS and healthy controls.
  • To determine if MS affects oxygen metabolism in the retinal vasculature.

Main Methods:

  • Noninvasive retinal oximetry was used to measure hemoglobin oxygen saturation.
  • Spectrophotometric imaging was employed for precise measurements.
  • Eight MS patients with a history of optic neuritis were compared with 22 age- and gender-matched healthy individuals.

Main Results:

  • Venular oxygen saturation was significantly higher in MS patients (70.7% ± 3.4%) versus controls (66.2% ± 4.7%).
  • The arteriovenous (AV) oxygen difference was lower in MS patients (26.6% ± 3.6%) compared to controls (30.5% ± 4.8%).
  • No significant difference in arteriolar oxygen saturation was observed between the groups.

Conclusions:

  • Elevated venular oxygen saturation and reduced AV difference in MS patients suggest potentially decreased oxygen consumption.
  • These retinal oximetry findings may indicate reduced metabolic demand secondary to retinal atrophy in MS.
  • Retinal oxygen saturation could serve as a novel, objective biomarker for multiple sclerosis, warranting further investigation.