A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus
Cheng-Shi Jiang1, Yan-Qiong Guo2, Sheng Yin2
1a School of Biological Science and Technology , University of Jinan , Jinan 250022 , China.
Abstract:
Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 0.96 ± 0.04 μM.
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