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Selective progesterone receptor modulators: current applications and perspectives.

N Chabbert-Buffet1, K Kolanska1, E Daraï1

  • 1a Obstetrics and Gynecology Department , University Hospital Paris Est, Tenon APHP, University Pierre and Marie Curie , Paris , France.

Climacteric : the Journal of the International Menopause Society
|January 18, 2018
PubMed
Summary
This summary is machine-generated.

Selective progesterone receptor modulators (SPRMs) offer advancements in women's health. These compounds are effective for emergency contraception and treating uterine fibroids by reducing bleeding and volume.

Keywords:
Progesterone receptorabnormal uterine bleedingemergency contraceptionmyoma

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Area of Science:

  • Pharmacology
  • Gynecology
  • Reproductive Medicine

Background:

  • Selective progesterone receptor modulators (SPRMs) are ligands targeting the progesterone receptor, exhibiting varied agonist/antagonist activities.
  • Mifepristone, a leading SPRM, was initially used for pregnancy termination and later for extended emergency contraception.
  • Ulipristal acetate, another SPRM, is now utilized for treating myoma-related uterine bleeding.

Purpose of the Study:

  • To review the applications and advancements of SPRMs in women's health.
  • To highlight the efficacy of SPRMs in emergency contraception and uterine fibroid management.
  • To explore the potential of SPRMs as alternatives in gynecological treatments.

Main Methods:

  • Literature review of SPRM applications.
  • Analysis of clinical data on mifepristone and ulipristal acetate.
  • Comparison of SPRM effects with existing treatments like GnRH analogs.

Main Results:

  • SPRMs have significantly improved emergency contraception options.
  • Ulipristal acetate effectively reduces uterine bleeding and myoma volume.
  • Unlike GnRH analogs, SPRMs do not suppress estradiol, offering benefits for women nearing menopause.

Conclusions:

  • SPRMs represent significant progress in emergency contraception and managing myoma-related symptoms.
  • The unique mechanism of SPRMs, preserving estradiol secretion, presents novel therapeutic avenues for uterine fibroids.
  • Further research is evaluating numerous future applications of SPRMs in women's healthcare.