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Updated: Feb 15, 2026

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer
07:46

In vivo Imaging and Therapeutic Treatments in an Orthotopic Mouse Model of Ovarian Cancer

Published on: August 17, 2010

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The latest animal models of ovarian cancer for novel drug discovery

Elizabeth Magnotti1, Wayne A Marasco1,2

  • 1a Department of Cancer Immunology and Virology , Dana-Farber Cancer Institute , Boston , MA , USA.

Expert Opinion on Drug Discovery
|January 18, 2018
PubMed
Abstract

Insights

Researchers reviewed mouse models for studying epithelial ovarian cancer, focusing on advancements in orthotopic and patient-derived xenograft models. Humanized models show promise for understanding the immune system

Area of Science:

  • Oncology
  • Immunology
  • Animal Models

Background:

  • Epithelial ovarian cancer is a complex disease with diverse subtypes.
  • Late-stage diagnosis and platinum resistance are common challenges.
  • Mouse models are crucial for understanding ovarian cancer development and treatment response.

Purpose of the Study:

  • To review current mouse models used in ovarian cancer research.
  • To highlight advances in orthotopic and patient-derived xenograft (PDX) models.
  • To discuss the potential of humanized mouse models in ovarian cancer research.

Main Methods:

  • Review of existing literature on ovarian cancer mouse models.
  • Focus on orthotopic and PDX model development.
  • Discussion of humanized mouse models, including NSG and NSG-SGM3 strains.

Main Results:

  • Orthotopic and PDX models offer valuable insights into ovarian cancer.
  • Humanized mouse models are emerging as a significant tool.
  • Advances in mouse strains are facilitating new research avenues.

Conclusions:

  • Humanized mouse models are expected to illuminate the role of the human immune system in ovarian cancer.
  • These models will aid in developing novel therapeutic strategies.
  • Continued development of advanced mouse models is essential for progress in ovarian cancer research.
Keywords:
Ovarian cancerhumanized mouse modelsorthotopicpatient-derived xenografts

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