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Updated: Feb 15, 2026

Introduction to the Ultrasound Targeted Microbubble Destruction Technique
Published on: June 12, 2011
Targeted microbubbles with ultrasound irradiation and PD-1 inhibitor to increase antitumor activity in B-cell
Shiya Zheng1, Dan Song2, Xiaoxiao Jin1
1Department of Oncology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.
Aim:
Severe cardiac toxicity of doxorubicin and an immunosuppressive tumor micro-environment become main obstacles for the effective treatment of B-cell lymphoma. In this research, rituximab-conjugated and doxorubicin-loaded microbubbles (RDMs) were designed for exploring a combination approach of targeted microbubbles with ultrasound (US) irradiation and PD-1 inhibitor to overcome obstacles mentioned above.
Methods:
In vivo studies were performed on SU-DHL-4 cell-grafted mice and ex vivo studies were performed on CD20+ human SU-DHL-4 cells and human T cells.
Results:
A greater therapeutic effect and higher expression of PD-L1 protein expression were obtained with RDMs with US irradiation in vivo. A significant inhibitory effect on SU-DHL-4 B-cell lymphoma cells was observed after treated by RDMs with US irradiation and PD-1 inhibitor ex vivo.
Conclusion:
Combination of RDMs with US irradiation and PD-1 inhibitor could be a promising therapeutic strategy for B-cell lymphoma.
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