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Use of the Open Field Maze to Measure Locomotor and Anxiety-like Behavior in Mice
Published on: February 6, 2015
Differential anxiety-like behavior, HPA responsiveness, and host-resistance in mice with different circling
Dongsoo Kim1, Hyojin Koo1, Kicheol Cheon2
1Department of Basic Science, Korea Air Force Academy, 635 Danjaero, Cheongju, Chungbuk 28187, Republic of Korea.
Abstract:
Relationships between behavioral sidedness and immune responses in previous studies have differed depending on behavior tests and severity of biological stress in mice. It was necessary to elucidate the psychophysiological mediators that connect behavioral sidedness and immune responses. This study investigated interrelationships among anxiety-like behavior, the HPA axis responsiveness, and host-resistance to bacterial infection. Mice that preferred clockwise circling had lower locomotor activities, higher anxiety-like behavior, and faster activation of the HPA axis than mice that preferred counterclockwise circling. A fast activation of the HPA axis was associated with a higher host-resistance to low dose bacterial infection.
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