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Inflammation

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Related Experiment Video

Updated: Feb 15, 2026

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

Published on: June 5, 2012

Helminth Modulation of Lung Inflammation.

Christian Schwartz¹, Emily Hams¹, Padraic G Fallon¹

¹School of Medicine, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin 2, Ireland.

Trends in Parasitology

|January 18, 2018

Summary

Parasitic helminths profoundly impact host immunity, influencing lung function and susceptibility to infections. This review explores helminth-induced pulmonary immune modulation and therapeutic potential.

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Last Updated: Feb 15, 2026

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation

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Published on: June 5, 2012

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

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Published on: May 30, 2020

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

A Microphysiological System to Study Leukocyte-Endothelial Cell Interaction during Inflammation

Published on: December 9, 2021

Area of Science:

Immunology
Parasitology
Pulmonology

Background:

Parasitic helminths are potent modulators of host physiology, coevolving with humans to shape immune system genes.
Helminth infections, while a health burden, can alter susceptibility to other diseases, sparking therapeutic interest.
Helminth products are being investigated for their potential to treat inflammatory and infectious conditions.

Purpose of the Study:

To review the impact of helminth infections on pulmonary immunity.
To examine helminth effects on homeostatic lung function.
To explore helminth influence on pulmonary viral and bacterial coinfections and asthma.

Main Methods:

Literature review of studies on helminth infections and pulmonary immunity.
Analysis of research on helminth modulation of host immune responses in the lungs.
Synthesis of findings regarding helminth impact on lung homeostasis, infections, and asthma.

Main Results:

Helminth infections significantly modulate pulmonary immune responses.
Helminths can influence lung homeostasis and susceptibility to viral and bacterial infections.
Evidence suggests helminths may have protective or exacerbating effects on asthma.

Conclusions:

Helminth infections have a complex impact on lung immunity, affecting homeostasis and disease susceptibility.
Understanding helminth-host interactions in the lung is crucial for developing novel therapeutic strategies.
Further research into helminth-derived molecules may yield new treatments for pulmonary diseases.