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Pterostilbene, a Potential MCR-1 Inhibitor That Enhances the Efficacy of Polymyxin B

Yonglin Zhou1, Shui Liu1, Tingting Wang1

  • 1Key Laboratory of Zoonosis, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Antimicrobial Agents and Chemotherapy
|January 18, 2018
PubMed

Insights

Pterostilbene and polymyxin B show a synergistic effect against MCR-producing Escherichia coli. Combination therapy eradicated the bacteria in vitro and significantly improved mouse survival rates in vivo.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • MCR-producing Escherichia coli strains are a growing public health concern.
  • Antibiotic resistance necessitates novel therapeutic strategies.

Purpose of the Study:

  • To investigate the synergistic antimicrobial effect of pterostilbene and polymyxin B.
  • To evaluate the efficacy of this combination against MCR-producing E. coli in vitro and in vivo.

Main Methods:

  • Fractional Inhibitory Concentration (FIC) index determination.
  • Time-killing assays.
  • In vivo mouse infection model.

Main Results:

  • Synergistic effect observed with FIC index of 0.156 or 0.188.
  • Combination therapy eradicated mcr-1 and NDM-positive E. coli within 1 hour.
  • Mouse survival increased from 0% to 60% with combination therapy.

Conclusions:

  • Pterostilbene and polymyxin B combination is a promising therapeutic approach.
  • This combination effectively combats MCR-producing E. coli.
  • Further research into clinical applications is warranted.
Keywords:
EnterobacteriaceaeMCR-1inhibitorpolymyxin Bpterostilbene

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