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Hematological Reference Intervals for Healthy Iranian Blood Donors
Mahboubeh Rasouli1, Mojgan Pourmokhtar2, Shaghayegh Sarkardeh3
1Department of Biostatics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
International Journal of Hematology-Oncology and Stem Cell Research
|January 18, 2018
Summary
Establishing local hematological reference intervals for Iranian blood donors is crucial. This study determined age and gender-specific ranges, highlighting significant differences from established norms.
Area of Science:
- Hematology
- Clinical Pathology
- Public Health
Background:
- Accurate health assessment relies on locally derived hematological reference intervals.
- Established intervals are influenced by demographic and environmental factors.
- This study addresses the need for region-specific data in Iran.
Purpose of the Study:
- To determine gender- and age-specific hematological reference intervals for healthy Iranian blood donors.
- To compare these intervals with existing data from the US population.
- To emphasize the importance of localized reference ranges for clinical interpretation.
Main Methods:
- Analysis of hematological indices from 394 healthy Iranian blood donors.
- Stratification of reference intervals by age and gender.
- Comparative analysis with US population data.
Main Results:
- Significant gender-based differences observed in Red Blood Cell (RBC), Hematocrit (HCT), and Mean Corpuscular Hemoglobin (MCH) values.
- Age-related variations noted for RBC and MCH.
- Iranian reference intervals showed similarities but narrower ranges compared to US data.
Conclusions:
- Gender and age-specific hematological reference intervals are essential for accurate interpretation of laboratory results in Iran.
- Locally derived intervals improve healthcare quality and clinical trial validity.
- This research provides a foundation for updated clinical guidelines in the region.
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