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Side alternating vibration training in patients with mitochondrial disease: a pilot study

Christopher Newell¹, Barbara Ramage², Ion Robu²

¹Department of Medical Science, Cumming School of Medicine, University of Calgary, Calgary, AB Canada.

Archives of Physiotherapy

|January 18, 2018

Abstract

Background:

Side alternating vibration training (SAVT) is a mechanical oscillation using a vibrating platform that simulates exercise. We hypothesized that patients with mitochondrial myopathies, who experience muscle weakness, may see an improvement in muscle power with SAVT.

Methods:

Patients with mitochondrial disease started either a treatment (SAVT) or control phase (standing without vibration) for 12 weeks, then 12 weeks of washout, and then a 12-week cross-over. The main outcome measure was peak jump power (PJP). We compared this to a natural history cohort from clinic.

Results:

Seven out of 13 patients completed at least 80% of their SAVT sessions and were analyzed. The ΔPJP after the control phase was -2.7 ± 1.7 W/kg (mean ± SEM), SAVT was +2.8 ± 0.6 W/kg (p < 0.05) and from the natural history cohort was -2.4 ± 0.8 W/kg/year.

Conclusions:

SAVT is well tolerated and may improve muscle power in mitochondrial disease patients.

Keywords:

Clinical measurement Mitochondrial disease Peak jumping power Pilot study Randomized controlled trial Side alternating vibration training Skeletal muscle

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