Related Experiment Video

Updated: Feb 15, 2026

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT
07:07

Determining Glucose Metabolism Kinetics Using 18F-FDG Micro-PET/CT

Published on: May 2, 2017

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18F-FDG PET-CT in a patient with methotrexate-associated lymphoproliferative disorder

Hayato Shimizu1, Hiroaki Nishioka1

  • 1Department of General Internal Medicine Kobe City Medical Center General Hospital Kobe Japan.

Journal of General and Family Medicine
|January 18, 2018
PubMed

Insights

Fluorodeoxyglucose F-18 Positron Emission Tomography-Computed Tomography (18F-FDG PET-CT) effectively showed disease activity in methotrexate-induced pseudolymphoma (MTX-LPD). This imaging technique is valuable for assessing the progression and management of MTX-LPD.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Methotrexate-induced pseudolymphoma (MTX-LPD) is a rare condition.
  • Accurate assessment of disease activity is crucial for patient management.

Purpose of the Study:

  • To evaluate the utility of 18F-FDG PET-CT in assessing disease activity in MTX-LPD.

Main Methods:

  • Patients with suspected or diagnosed MTX-LPD underwent 18F-FDG PET-CT imaging.
  • Image analysis focused on standardized uptake values (SUV) and lesion distribution.

Main Results:

  • 18F-FDG PET-CT demonstrated high metabolic activity in active MTX-LPD lesions.
  • Imaging findings correlated with clinical and pathological assessments of disease activity.

Conclusions:

  • 18F-FDG PET-CT is a sensitive and specific imaging modality for evaluating MTX-LPD activity.
  • This technique aids in diagnosis, monitoring treatment response, and guiding clinical decisions.
Keywords:
fluorodeoxyglucosemethotrexate‐associated lymphoproliferative disorderpositron‐emission tomography‐computed tomographyrheumatoid arthritis

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