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Visual Fixation Instability in Multiple Sclerosis Measured Using SLO-OCT.

Robert M Mallery1,2, Pieter Poolman3,4, Matthew J Thurtell3,5

  • 1Department of Neurology, Brigham and Women's Hospital, Boston, Massachusetts, United States.

Investigative Ophthalmology & Visual Science
|January 18, 2018
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Summary
This summary is machine-generated.

Visual fixation instability is elevated in multiple sclerosis (MS) patients, even those without optic neuritis, indicating neural network dysfunction. This measure may help monitor MS progression and treatment effectiveness.

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Medical Imaging

Background:

  • Multiple sclerosis (MS) involves neural network dysfunction.
  • Optical coherence tomography (OCT) and scanning laser ophthalmoscope (SLO) are advanced imaging techniques.
  • Visual fixation instability can be a marker of neurological conditions.

Purpose of the Study:

  • To measure visual fixation instability using OCT.
  • To assess fixation instability as a marker of neural network dysfunction in MS.
  • To explore its potential for monitoring MS progression and treatment response.

Main Methods:

  • 16 MS patients and 26 controls underwent SLO-based eye tracking during OCT.
  • Fixation instability was quantified using kernel density estimation.
  • Groups included normal eyes, MS eyes without prior optic neuritis (MS wo ON), and MS eyes with prior optic neuritis (MS + ON).

Main Results:

  • Fixation instability was significantly higher in MS wo ON eyes compared to normal eyes (0.062 deg2 vs 0.030 deg2).
  • MS + ON eyes showed further increased fixation instability compared to both MS wo ON and normal eyes (0.11 deg2).
  • Fixation instability showed a weak correlation with ganglion cell layer (GCL) volume but not with EDSS or SDMT scores.

Conclusions:

  • Fixation instability is disturbed in MS, reflecting widespread neural network impairment.
  • Further research into visual fixation, including microsaccades, can localize abnormalities in MS.
  • This easily measured outcome may offer innovative ways to monitor MS progression and treatment.