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PRP as a New Approach to Prevent Infection: Preparation and In vitro Antimicrobial Properties of PRP
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Do bioresorbable polyesters have antimicrobial properties?

Lukas Gritsch1,2, Christopher Lovell2, Wolfgang H Goldmann3

  • 1Institute of Biomaterials, University of Erlangen-Nuremberg, Cauerstraße 6, 91058, Erlangen, Germany.

Journal of Materials Science. Materials in Medicine
|January 18, 2018
PubMed
Summary
This summary is machine-generated.

Biodegradable and bioresorbable polyesters (BBPEs) do not inherently kill bacteria. Their slow degradation means acidic by-products do not immediately inhibit pathogen growth, contrary to some speculation.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Medical Device Development

Background:

  • Biodegradable and bioresorbable polyesters (BBPEs) are widely used in medical applications.
  • Speculation exists regarding BBPEs possessing intrinsic antibacterial activity due to acidic degradation products.
  • The hypothesis suggests that in vivo hydrolysis and subsequent pH drop could inhibit local pathogen growth.

Purpose of the Study:

  • To investigate the intrinsic antibacterial properties of commercially available BBPEs.
  • To provide conclusive evidence regarding the antibacterial activity of BBPEs.
  • To assess the potential of BBPE degradation by-products to inhibit bacterial growth.

Main Methods:

  • Evaluation of six well-established, commercially available BBPEs.
  • Utilized agar diffusion assays to observe bacterial growth and inhibition zones.
  • Employed optical density measurements (OD600) to quantify bacterial proliferation over 24 hours.

Main Results:

  • No intrinsic and immediate antibacterial activity was observed for the tested BBPEs.
  • Bacterial growth was not significantly inhibited by the presence of the BBPE samples within the 24-hour incubation period.
  • The rate of polyester degradation is considerably slower than the typical timescale for bacterial growth.

Conclusions:

  • BBPEs do not exhibit inherent antibacterial properties.
  • The hypothesis of antibacterial activity via acidic degradation by-products is not supported by immediate in vitro testing.
  • Clinical implications for BBPE-based devices should consider the lack of intrinsic antimicrobial effect.