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New Strategies for Improving the Development and Performance of Amorphous Solid Dispersions
Abbe Haser1, Feng Zhang2,3
1Division of Pharmaceutics, College of Pharmacy, the University of Texas at Austin, 2409 University Avenue, A1920, Austin, Texas, 78712, USA.
AAPS Pharmscitech
|January 18, 2018
Summary
Amorphous solid dispersions (ASDs) are crucial for poorly soluble drugs. This review details strategies to enhance ASD development, focusing on prediction, manufacturing, and stability for improved drug performance.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
Background:
- Amorphous solid dispersions (ASDs) are key enabling technologies for formulating poorly soluble compounds.
- The number of approved commercial ASD products highlights their significance in drug development.
Purpose of the Study:
- To review recent strategies for improving the development and performance of amorphous solid dispersions (ASDs).
- To present benefits, limitations, and case studies of various ASD improvement strategies.
Main Methods:
- Literature review of recently reported strategies for ASD development.
- Categorization of strategies into prediction techniques, manufacturing considerations, and stability enhancement.
Main Results:
- Identified strategies focus on enabling early formulation decisions through prediction techniques.
- Manufacturing considerations aim to produce physically and chemically stable ASDs.
- Strategies address overcoming degradation, phase separation, and optimizing dissolution behavior.
Conclusions:
- Continuous advancements are needed to optimize ASD development and performance.
- Effective strategies can lead to more stable and bioavailable amorphous solid dispersion formulations.
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