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MRI in the Study of Animal Models of Neurodegenerative Diseases

Nyoman D Kurniawan1

  • 1Centre for Advanced Imaging, The University of Queensland, St. Lucia, QLD, Australia. n.kurniawan@uq.edu.au.

Methods in Molecular Biology (Clifton, N.J.)
|January 18, 2018
PubMed

Insights

Magnetic Resonance Imaging (MRI) provides essential insights into animal models of degenerative diseases. This chapter details MRI protocols for rodent brain and spinal cord, enabling measurement of tissue damage and connectivity changes.

Area of Science:

  • Neuroscience
  • Medical Imaging

Background:

  • Degenerative diseases impact the central nervous system.
  • Animal models are crucial for studying these diseases.
  • Magnetic Resonance Imaging (MRI) offers non-invasive visualization of tissue.

Purpose of the Study:

  • To describe standard Magnetic Resonance Imaging (MRI) protocols for rodent central nervous system research.
  • To provide methods for assessing neurodegeneration in animal models using MRI.

Main Methods:

  • Detailed protocols for T1-, T2-, and T2*-weighted MRI sequences.
  • Inclusion of diffusion-weighted imaging (DWI) for white matter analysis.
  • Application to rodent brain and spinal cord imaging.

Main Results:

  • Established MRI protocols for routine use in animal research.
  • Demonstrated MRI's capability to quantify key markers of neurodegeneration.
  • Enabled measurement of atrophy, axonal injury, and myelin damage.

Conclusions:

  • Standardized MRI protocols facilitate robust assessment of neurodegenerative changes in rodents.
  • These methods are vital for advancing research into degenerative diseases using animal models.
  • MRI techniques allow for comprehensive evaluation of white matter integrity and connectivity.
Keywords:
Animal model of neurodegenerative diseasesBrainDiffusion tensor imagingDiffusion-weighted imagingEx vivo MRIHigh-field MRIIn vivo MRIMagnetic Resonance ImagingSpinal cord

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