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Updated: Feb 15, 2026
08:32
Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
Published on: November 24, 2017
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Can Neonatal Brain MRI be Performed during Active Cooling?
Marisa J Pacella1, Dhanashree A Rajderkar2, Nicole Copenhaver1
1Department of Pediatrics, University of Florida, Gainesville, Florida.
American Journal of Perinatology
|January 18, 2018
Summary
Diagnostic imaging for neonatal hypoxic-ischemic encephalopathy (HIE) is often delayed. This case demonstrates that magnetic resonance imaging (MRI) is feasible during active hypothermia, even before the standard 72-hour period.
Area of Science:
- Neonatal neurology
- Diagnostic imaging
- Therapeutic hypothermia
Background:
- Neonatal hypoxic-ischemic encephalopathy (HIE) management involves therapeutic hypothermia for 72 hours.
- Diagnostic imaging is typically delayed until after rewarming due to logistical challenges.
Observation:
- A case report details a magnetic resonance imaging (MRI) scan performed during active therapeutic hypothermia.
- The neonate's temperature remained stable at 33.6°C during the MRI, indicating successful maintenance of hypothermia.
Findings:
- Active therapeutic hypothermia can be safely maintained during MRI acquisition in neonates.
- This challenges the traditional practice of delaying neuroimaging.
Implications:
- Neuroimaging during active hypothermia may provide earlier diagnostic information for HIE.
- This approach could potentially optimize treatment strategies and outcomes for affected neonates.
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