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Updated: Feb 15, 2026

Neurobehavioral Assessments in a Mouse Model of Neonatal Hypoxic-ischemic Brain Injury
Published on: November 24, 2017
Can Neonatal Brain MRI be Performed during Active Cooling?
Marisa J Pacella1, Dhanashree A Rajderkar2, Nicole Copenhaver1
1Department of Pediatrics, University of Florida, Gainesville, Florida.
Objective:
Due to logistical constraints, physicians traditionally delay diagnostic imaging for neonatal hypoxic-ischemic encephalopathy (HIE) until the neonate has completed all 72 hours of therapeutic hypothermia and rewarming. In some cases, neonates may require neuroimaging before 72 hours has passed.
Study Design:
We present a case in which an MRI was acquired during active hypothermia.
Results:
Upon return to the NICU, Baby X's temperature probe read 33.6 degrees, indicating that hypothermia was likely maintained at the target temperature.
Conclusion:
Active hypothermia is possible during MRI.
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