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Recurrent terbinafine resistant Trichophyton rubrum infection in a child with congenital ichthyosis

Louise Schøsler1, Louise Kronborg Andersen1, Maiken Cavling Arendrup2,3,4

  • 1Department of Dermato-Venereology, Aarhus University Hospital, Aarhus C, Denmark.

Pediatric Dermatology
|January 18, 2018
PubMed

Insights

Terbinafine resistance in children with T. rubrum dermatophytosis is a growing concern. This case highlights a rare instance of terbinafine resistance in a child with congenital ichthyosiform erythroderma.

Area of Science:

  • Medical Mycology
  • Pediatric Dermatology
  • Antimicrobial Resistance

Background:

  • Dermatophytosis is a common fungal infection in children.
  • Trichophyton rubrum is a frequent cause of pediatric dermatophytosis.
  • Terbinafine is the standard first-line treatment for T. rubrum infections.

Observation:

  • A child with recurrent T. rubrum dermatophytosis and congenital ichthyosiform erythroderma was treated.
  • The patient exhibited resistance to both topical and systemic terbinafine therapy.
  • This represents the first reported case of terbinafine resistance in this specific pediatric population.

Findings:

  • Recurrent T. rubrum infections can develop resistance to terbinafine.
  • Congenital ichthyosiform erythroderma may be associated with treatment challenges in dermatophytosis.
  • Standard antifungal treatments may not be effective in all pediatric cases.

Implications:

  • The emergence of terbinafine resistance necessitates alternative treatment strategies for pediatric dermatophytosis.
  • Further research is needed to understand the mechanisms of terbinafine resistance in T. rubrum.
  • Clinicians should consider alternative antifungal agents for refractory cases, especially in patients with underlying skin conditions.

Keywords:
antifungal treatmentdermatophytosisichthyosisresistance

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