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Updated: Feb 15, 2026

Doppler Optical Coherence Tomography of Retinal Circulation
Published on: September 18, 2012
Automated detection of preserved photoreceptor on optical coherence tomography in choroideremia based on machine
Zhuo Wang1,2, Acner Camino1, Ahmed M Hagag1
1Casey Eye Institute, Oregon Health and Science University, Portland, Oregon.
Abstract:
Optical coherence tomography (OCT) can demonstrate early deterioration of the photoreceptor integrity caused by inherited retinal degeneration diseases (IRDs). A machine learning method based on random forests was developed to automatically detect continuous areas of preserved ellipsoid zone structure (an easily recognizable part of the photoreceptors on OCT) in 16 eyes of patients with choroideremia (a type of IRD). Pseudopodial extensions protruding from the preserved ellipsoid zone areas are detected separately by a local active contour routine. The algorithm is implemented on en face images with minimum segmentation requirements, only needing delineation of the Bruch's membrane, thus evading the inaccuracies and technical challenges associated with automatic segmentation of the ellipsoid zone in eyes with severe retinal degeneration.
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