Related Experiment Video
Updated: Feb 15, 2026

Synthesis of Protein Bioconjugates via Cysteine-maleimide Chemistry
Published on: July 20, 2016
Application of Decafluorobiphenyl (DFBP) Moiety as a Linker in Bioconjugation
Saba Alapour1, Beatriz G de la Torre2, Deresh Ramjugernath3
1School of Chemistry and Physics, University of KwaZulu-Natal , Private Bag X54001, Durban 4000, South Africa.
Abstract:
Considerable attention has been devoted to fluorinated compounds due to their unique and interesting properties. Many modern pharmaceuticals contain fluorinated substituents, which are commonly synthesized using selective fluorinating reagents. Decafluorobiphenyl (DFBP) as a fluorinated linker is susceptible to nucleophilic attack. This nucleophilic reaction has been widely studied using various nucleophiles. Sulfur and nitrogen containing nucleophiles have been of particular interest, especially in bioconjugated reactions. This review focuses on the SNAr reactivity of DFBP in formation of C-X (X = S, N) bonds, to be applied in bioconjugation in organic chemistry. The review aims to highlight the crucial factors that govern the chemistry behind the activation of F-CAr-CAr-F bonds as a linker in the synthesis of novel peptides, proteins, and biologics.
More Related Videos
08:47Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
07:14Author Spotlight: Experimental Approaches for the Synthesis of Low-Valent Metal-Organic Frameworks from Multitopic Phosphine Linkers
Published on: May 12, 2023
Related Concept Videos
Cytoskeletal Linker Proteins - Plakins
Applications of Logarithms
Photoluminescence: Applications
Radiation: Applications
The average...
Applications of Stress
The...
Environmental Applications of Microorganisms