Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Does endogenous dopamine modulate human sympathetic activity through DA2 receptors?

M Mannelli, M L De Feo, M Maggi

    European Journal of Clinical Pharmacology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The use of bone-modifying agents in early breast cancer: AIOM Guidelines update and perspectives.

    Tumori·2025
    Same author

    PREDICTIVE BRCA GENETIC TESTING IN ITALIAN PATIENTS WITH BREAST CANCER: A POSITION PAPER OF ITALIAN SCIENTIFIC SOCIETIES [Italian Association of Medical Oncology(AIOM); Italian Association of Radiotherapy and Clinical Oncology (AIRO); Italian National Association of Breast Surgeons (ANISC); Italian Society of Pathological Anatomy and Diagnostic Cytology (SIAPeC-IAP); Italian Society of Surgical Oncology (SICO); Italian Society of Human Genetic (SIGU); Italian Society of General Practice (SIMG); Italian Society of Medical and Interventional Radiology (SIRM)].

    Cancer treatment reviews·2025
    Same author

    Capsid Engineering Overcomes Barriers Toward Adeno-Associated Virus Vector-Mediated Transduction of Endothelial Cells.

    Human gene therapy·2019
    Same author

    Host and symbiont intraspecific variability: The case of Paramecium calkinsi and "Candidatus Trichorickettsia mobilis".

    European journal of protistology·2017
    Same author

    Delivery of therapeutic proteins from genetically-modified cells.

    Restorative neurology and neuroscience·2011
    Same author

    Obesity in the childhood: a link to adult hypertension.

    Current pharmaceutical design·2009

    Dopamine D2 receptor blockers did not alter catecholamine levels during rest or sympathetic stress. This suggests dopamine does not significantly influence norepinephrine release in humans under normal physiological conditions.

    Area of Science:

    • Neuropharmacology
    • Autonomic Nervous System Physiology

    Background:

    • Catecholamines (CA), such as norepinephrine, are key neurotransmitters in the sympathetic nervous system.
    • Dopamine D2 (DA2) receptors are implicated in various physiological processes, but their role in catecholamine release modulation is not fully understood.

    Purpose of the Study:

    • To investigate the impact of DA2 antidopaminergic agents on basal and stimulated catecholamine plasma levels in humans.
    • To determine if endogenous dopamine plays a role in modulating norepinephrine release during sympathetic stimulation.

    Main Methods:

    • Administration of domperidone (peripheral DA2 blockade) or metoclopramide (central and peripheral DA2 blockade) to separate human subject groups.
    • Sympathetic stimulation induced via handgrip, cold pressor tests, and standing.

    Related Experiment Videos

    Main Results:

    • Neither domperidone nor metoclopramide administration affected plasma catecholamine levels at rest.
    • DA2 receptor blockade did not alter plasma catecholamine levels during acute sympathetic stimulation.

    Conclusions:

    • Pharmacological blockade of dopamine D2 receptors does not influence catecholamine levels in humans.
    • Endogenous dopamine does not appear to significantly modulate norepinephrine release under the tested physiological conditions.