Is the ANS linked to mathematics performance?
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Updated: Feb 15, 2026

Chemical Modification of the Tryptophan Residue in a Recombinant Ca2+-ATPase N-domain for Studying Tryptophan-ANS FRET
Published on: October 9, 2021
Matthew Inglis1, Sophie Batchelor1, Camilla Gilmore1
1Mathematics Education Centre,Loughborough University,Loughborough,Leicestershire LE11 3TU,United Kingdomm.j.inglis@lboro.ac.uks.m.batchelor@lboro.ac.ukc.gilmore@lboro.ac.ukhttp://mcg.lboro.ac.uk/mjihttp://mcg.lboro.ac.uk/sbhttp://mcg.lboro.ac.uk/cg.
Abstract:
Leibovich et al. argue persuasively that researchers should not assume that approximate number system (ANS) tasks harness an innate sense of number. However, some studies have reported a causal link between ANS tasks and mathematics performance, implicating the ANS in the development of numerical skills. Here we report a p-curve analysis, which indicates that these experimental studies do not contain evidential value.
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