[Comparative evaluation of cardiotropic effects of nicamag, panangin and asparkam]

Experiments on 75 dogs with experimental myocardial infarction were made to study and compare the therapeutic effect of nicamag (a mixture of potassium and magnesium nicotinates) in a dose of 10 mg/kg, panangin and asparkam (potassium and magnesium aspartates). Nicamag rapidly precipitated postinfarction arrhythmia and made the ECG completely return to normal in the majority of cases. A beneficial effect of the drug on carbohydrate, energy and electrolyte metabolism in the myocardium was discovered to underlie the above-described action. Nicamag abruptly lowered the titers of cardial antibodies, increased the fibrinalytic activity of the blood which is accounted for by the effect of the anion--nicotinic acid.