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Lipoprotein metabolism and lipoprotein lipase in severe cystic acne
Insights
Severe cystic acne is linked to lower levels of high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A), potentially increasing atherosclerosis risk. Further research is needed to understand this connection.
Area of Science:
- Dermatology
- Cardiovascular Health
- Lipid Metabolism
Background:
- Severe cystic acne patients exhibit altered lipid profiles.
- Low high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) are observed.
- These lipid changes occur despite normal total lipid levels.
Purpose of the Study:
- To investigate lipid profiles in severe cystic acne.
- To compare HDL-C and Apo-A levels with controls and acne vulgaris patients.
- To explore the relationship between cystic acne and atherosclerosis risk factors.
Main Methods:
- Assessed high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) levels.
- Measured lipoprotein lipase activity in hepatic and extra-hepatic tissues.
- Analyzed HDL subclass distribution using zonal ultracentrifugation.
Main Results:
- Significantly lower HDL-C and Apo-A levels were found in cystic acne patients compared to controls.
- Reduced total and hepatic lipase activity was observed.
- A decrease in the HDL2 subclass was identified.
Conclusions:
- Severe cystic acne is associated with reduced HDL-C and Apo-A.
- Lipase deficiency may contribute to altered HDL metabolism in cystic acne.
- Cystic acne may represent a risk factor for atherosclerosis due to low HDL levels.
Abstract:
In severe cystic acne we found low levels of high density lipoprotein-cholesterol (HDL-C) and apolipoprotein A (Apo-A) in the presence of normal total lipids. In a larger number of patients, we always observed significantly lower levels of HDL-C and Apo-A than in either age-matched controls or subjects with acne vulgaris. Since lipoprotein lipase is one major determinant of HDL concentration, we assayed the lipase activity in liver and extra-hepatic tissues by the method of Krauss et al. There was highly significant less total and hepatic lipase activity than in age-matched controls. HDL distribution was examined by zonal ultracentrifugation and a decrease in the HDL2 subclass was discovered. Since HDL are inversely correlated to atherosclerosis, cystic acne is one risk factor for atherosclerosis. The linkage between low HDL levels and severe cystic acne should be further investigated.