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Calcium Phosphates as Delivery Systems for Bisphosphonates.
1Department of Chemistry "G. Ciamician", University of Bologna, 40126 Bologna, Italy. adriana.bigi@unibo.it.
Journal of Functional Biomaterials
|January 19, 2018
Summary
Bisphosphonates (BPs) delivered via calcium phosphates offer targeted osteoporosis and bone metastasis treatment. This review details BP-calcium phosphate interactions and their use as bone biomaterials.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Bone Biology
Background:
- Bisphosphonates (BPs) are primary treatments for osteoporosis and bone metastases, targeting high bone resorption.
- Systemic BP use can cause side effects; local delivery to bone is desirable.
- Calcium phosphates exhibit high affinity for BPs, making them suitable bone-targeting delivery vehicles.
Purpose of the Study:
- To review the interactions between bisphosphonate molecules and calcium phosphates.
- To highlight recent advancements in BP-functionalized calcium phosphates as biomaterials for bone repair and substitution.
Main Methods:
- Overview of studies on bisphosphonate-calcium phosphate interactions.
- Review of synthesis methods: direct synthesis in aqueous medium and chemisorption from solution.
- Analysis of recent applications in bone biomaterials.
Main Results:
- Calcium phosphates effectively bind bisphosphonates due to their calcium-binding properties.
- Two primary synthesis routes, direct synthesis and chemisorption, are established for BP-functionalized calcium phosphates.
- BP-functionalized calcium phosphates show promise as bone substitutes and in promoting bone repair.
Conclusions:
- Bisphosphonate-functionalized calcium phosphates represent a promising strategy for localized bone treatment.
- These biomaterials offer a way to enhance therapeutic efficacy while minimizing systemic side effects.
- Further research into their application in bone substitution and repair is warranted.
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