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Updated: Feb 15, 2026

Methylated DNA Immunoprecipitation
Published on: January 2, 2009
MACON: a web tool for computing DNA methylation data obtained by the Illumina Infinium Human DNA methylation
Naoko Iida1, Yoshihiro Okuda2, Osamu Ogasawara2
1Division of Epigenomics, National Cancer Center Research Institute, Tokyo, Japan.
Aim:
Bioinformatics analysis for Illumina Infinium Human DNA methylation BeadArray is essential, but still remains difficult task for many experimental researchers. We here aimed to develop a browser-accessible bioinformatics tool for analyzing the BeadArray data.
Materials & Methods:
The tool was established as an analytical pipeline using R, Perl and Python programming languages.
Results:
We introduced a method that groups neighboring probes into a genomic block, which facilitated efficient identification of densely methylated/unmethylated regions. The tool, MACON, provided probe filtering, β-mixture quantile normalization, grouping into genomic blocks, annotation and production of a data subset.
Conclusion:
MACON allows researchers to analyze the BeadArray data using a web browser ( http://epigenome.ncc.go.jp/macon ).
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