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Prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances and childhood atopic dermatitis: a prospective

Qian Chen1, Rong Huang1, Li Hua2

  • 1Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China.

Environmental Health : a Global Access Science Source
|January 19, 2018
PubMed

Insights

Prenatal exposure to certain PFASs, like PFOA and PFNA, significantly increases the risk of atopic dermatitis (AD) in infant girls. These findings highlight potential environmental health risks for children exposed to these common chemicals.

Area of Science:

  • Environmental Health
  • Pediatric Allergy
  • Toxicology

Background:

  • Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are widespread environmental contaminants.
  • Previous research on prenatal PFAS exposure and offspring allergic disorders yielded inconsistent results.
  • Immune-suppressive effects of PFASs are documented, necessitating further investigation into their role in allergic diseases.

Purpose of the Study:

  • To investigate the association between prenatal exposure to various PFASs and the development of childhood atopic dermatitis (AD).
  • To assess this association in offspring up to 24 months of age.
  • To determine if sex influences the relationship between prenatal PFAS exposure and AD.

Main Methods:

  • A prospective birth cohort study included 1056 pregnant women in Shanghai (2012-2015).
  • Prenatal PFAS levels were measured in umbilical cord blood plasma.
  • Children were followed for AD diagnosis at 6, 12, and 24 months using standardized criteria and logistic regression analysis.

Main Results:

  • AD was diagnosed in 25.2% of 687 children with complete follow-up and PFAS data.
  • Prenatal exposure to perfluorooctanoic acid (PFOA) and perfluorododecanoic acid (PFDoA) significantly increased AD risk in female infants.
  • Elevated risks were also observed for perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorohexane sulfonic acid (PFHxS) in girls, with no significant associations found in boys.

Conclusions:

  • Prenatal exposure to specific PFASs (PFOA, PFDA, PFDoA, PFHxS) is linked to a higher risk of childhood AD in female offspring.
  • The association between prenatal PFNA exposure and AD risk approached statistical significance.
  • These findings underscore the potential sex-specific impact of prenatal PFAS exposure on allergic disease development.
Abstract

Keywords:
Atopic dermatitisChildhoodCord bloodExposurePerfluoroalkyl and polyfluoroalkyl substances

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