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Updated: Feb 15, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Decompensated labyrinthine weakness presenting as de novo peripheral vertigo: a discrete clinical entity?
1Department of Otolaryngology,Mount Sinai West Hospital Center,New York,USA.
Objective:
A distinct subgroup of patients, presenting with apparently spontaneous onset of vertigo, is described.
Results:
Although vestibular evaluation revealed caloric weakness, the proximate cause of vertigo was not labyrinthine dysfunction, but rather the loss of vestibular compensation for an older and previously compensated labyrinthine injury.
Conclusion:
Instead of addressing the vestibular weakness, effective management needs to focus on the condition that has caused the loss of compensation.
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