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Updated: Feb 15, 2026
06:53
Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
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A Long-Distance Relay-tionship between Tumor and Bone.
Klara Soukup1, Johanna A Joyce1
1Ludwig Institute for Cancer Research, University of Lausanne, Lausanne, Switzerland; Department of Oncology, University of Lausanne, Lausanne, Switzerland.
Immunity
|January 19, 2018
Summary
Lung tumors recruit neutrophils via a bone cell relay mechanism. This process sustains a supply of tumor-promoting neutrophils, impacting cancer growth and metastasis.
Area of Science:
- Oncology
- Immunology
- Cell Biology
Background:
- Myeloid cells, particularly neutrophils, play a critical role in regulating tumor progression and metastasis.
- Understanding the mechanisms by which tumors influence immune cells is crucial for developing effective cancer therapies.
Purpose of the Study:
- To investigate how lung tumors establish a sustained supply of tumor-promoting neutrophils.
- To elucidate the role of bone-resident cells in mediating this neutrophil recruitment.
Main Methods:
- The study utilized mouse models of lung cancer.
- Engblom et al. employed techniques to track immune cell populations and their interactions.
- Investigated the communication pathways between tumor cells and bone marrow.
Main Results:
- Lung tumors were found to remotely engage bone-resident cells.
- A relay mechanism involving bone cells was identified, facilitating neutrophil mobilization.
- This mechanism ensures a continuous supply of neutrophils that promote tumor growth.
Conclusions:
- Tumor-induced activation of bone cells is essential for sustaining neutrophil supply.
- Targeting this bone-lung communication axis could offer novel therapeutic strategies against lung cancer metastasis.
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