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Optimizing strategies for laser angioplasty.

P M Selzer, D Murphy-Chutorian, R Ginsburg

    Investigative Radiology
    |November 1, 1985
    PubMed
    Summary
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    A pulsed ultraviolet laser is proposed as a safer, more effective tool for laser angioplasty than continuous wave argon lasers. This pulsed laser offers better recanalization potential for vascular tissues.

    Area of Science:

    • Biomedical Optics
    • Vascular Surgery
    • Laser Physics

    Background:

    • Understanding the optical properties of vascular tissues is crucial for developing effective laser angioplasty techniques.
    • Differences in light absorption between normal and diseased tissues guide the selection of optimal laser parameters.

    Purpose of the Study:

    • To investigate the intrinsic optical properties of normal and diseased vascular tissues.
    • To determine the optimal laser source for laser angioplasty by examining tissue interaction with continuous wave (CW) and pulsed laser light.

    Main Methods:

    • Analysis of spectral absorbance of normal intima and atheromatous plaque at various wavelengths.
    • Evaluation of tissue damage thresholds for CW argon laser and high-power pulsed ultraviolet (UV) laser.

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  • Investigation of the nonlinear response of tissue to pulsed UV laser by varying pulse repetition rate and energy.

    • Main Results:

    • Both normal intima and atheromatous plaque showed increased spectral absorbance at shorter wavelengths (near UV).
    • Selective ablation of plaque was not achievable due to insufficient absorbance differences between tissues.
    • Pulsed UV laser interaction with tissue exhibited a nonlinear response.
    • Pulsed UV laser demonstrated potential for safer and more effective recanalization compared to CW argon laser.

    Conclusions:

    • A pulsed ultraviolet laser, specifically with 50 mJ/pulse and 10 pps, is proposed as a superior option for laser angioplasty.
    • This pulsed UV laser configuration offers improved safety and efficacy for vascular recanalization over CW argon lasers.