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Localization of the Locus Coeruleus in the Mouse Brain
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A genetic locus for paranoia.

Bernard Crespi1, Silven Read2, Iiro Salminen2

  • 1Department of Biological Sciences, Simon Fraser University, 8888 University Drive, Burnaby, British Columbia, Canada V5A 1S6 crespi@sfu.ca.

Biology Letters
|January 19, 2018
PubMed
Summary
This summary is machine-generated.

Genomic imprinting influences psychological traits. A specific gene variant (rs850807) is linked to paranoia, suggesting imprinted genes impact human thought processes.

Keywords:
Prader–Willigenomic imprintingmagel2necdinparanoia

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Area of Science:

  • Neurogenetics
  • Psychology
  • Genomics

Background:

  • Psychological effects of brain-expressed imprinted genes remain largely unknown.
  • Prader-Willi syndrome (PWS) involves psychosis and autism, linked to imprinted genes MAGEL2 and NDN.
  • Altered MAGEL2 and NDN expression affects mouse behavior.

Purpose of the Study:

  • Investigate the psychological effects of brain-expressed imprinted genes in humans.
  • Examine the association between genetic variation in rs850807 and schizophrenia/autism spectrum traits.
  • Develop a genetic model for paranoid thinking.

Main Methods:

  • Phenotyped a large population for schizophrenia-spectrum and autism-spectrum traits.
  • Genotyped individuals for the single-nucleotide polymorphism rs850807.
  • Analyzed the association between rs850807 variation and psychological traits.

Main Results:

  • Genetic variation in rs850807 was strongly associated with the ideas of reference subscale (paranoia) of the schizophrenia spectrum.
  • The association was exclusive to paranoia, not other schizophrenia or autism spectrum traits.
  • rs850807 is putatively functional and linked with MAGEL2 and NDN.

Conclusions:

  • Findings provide a single-locus genetic model for analyzing the neurological and psychological basis of paranoid thinking.
  • Imprinted genes and genomic conflicts are implicated in human mentalistic thought.
  • This study sheds light on the genetic underpinnings of psychological conditions.