Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

6.2K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.2K
Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

106.0K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
106.0K
What is Genetic Engineering?00:49

What is Genetic Engineering?

80.4K
Overview
80.4K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

1.2K
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.2K
Personal Identity01:25

Personal Identity

475
Personal identity is the deeply felt sense of self that individuals cultivate over time, intricately woven from intrinsic qualities they consider essential to their existence—qualities such as morality, intelligence, and friendliness. These attributes serve as vital internal benchmarks, guiding individuals in evaluating whether their actions resonate with their true selves.When personal identity takes center stage in one's life, individuals often emphasize their distinctiveness,...
475
Accuracy and Precision01:52

Accuracy and Precision

15.9K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate...
15.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Spatial and Single-Cell Mapping Reveals Valvular Interstitial Cell and Macrophage Sex Differences in Calcific Aortic Valve Disease.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

Leveraging bond dissociation kinetics to tune shear-thickening behavior in dynamic covalent tetra-PEG hydrogels.

Science advances·2026
Same author

Circulating biomarkers in serum from aortic valve stenosis patients predict sex-specific drug responses in valve myofibroblasts.

bioRxiv : the preprint server for biology·2026
Same author

Transforming Growth Factor β1 Modulates Sex Differences in Cardiac Myofibroblast Activation on Hydrogel Biomaterials.

bioRxiv : the preprint server for biology·2026
Same author

Peptomer Linkers Enable Kinetic Control over Co-Delivery of Multiple Chemotherapeutics.

Advanced healthcare materials·2025
Same author

Tuning Scaffold Degradation with Non-Natural Peptidomimetics to Control Human Umbilical Vein Endothelial Cell Morphology and Vessel Formation.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Feb 15, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K

Engineering precision biomaterials for personalized medicine.

Brian A Aguado1,2,3, Joseph C Grim1,2,3, Adrianne M Rosales1,2

  • 1Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309, USA.

Science Translational Medicine
|January 19, 2018
PubMed
Summary
This summary is machine-generated.

Biomaterial device design is evolving beyond a "one-size-fits-all" approach for precision medicine. An engineering strategy using unit operations offers a unified framework to accelerate the development of personalized medical devices.

More Related Videos

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine
08:35

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine

Published on: April 22, 2022

3.5K
Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

14.0K

Related Experiment Videos

Last Updated: Feb 15, 2026

Culture of Bladder Cancer Organoids as Precision Medicine Tools
08:39

Culture of Bladder Cancer Organoids as Precision Medicine Tools

Published on: December 28, 2021

5.5K
Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine
08:35

Primary Human Nasal Epithelial Cells: Biobanking in the Context of Precision Medicine

Published on: April 22, 2022

3.5K
Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

14.0K

Area of Science:

  • Biomaterials Science
  • Biomedical Engineering
  • Precision Medicine

Background:

  • The "one-size-fits-all" approach in medical device and therapy design is insufficient for the growing demand for precision medicine.
  • Individual patient complexity requires multifunctional devices for personalized therapies.
  • Biomaterials offer significant potential for advancing precision medicine.

Purpose of the Study:

  • To introduce a novel engineering strategy for designing biomaterial-based medical devices.
  • To provide a unified vocabulary and contextual framework for biomaterial device design.
  • To accelerate the translation of personalized biomaterial therapies.

Main Methods:

  • Development of an engineering strategy based on the concept of unit operations.
  • Application of a unified framework to guide the design process.
  • Focus on integrating multiple functions into single biomaterial devices.

Main Results:

  • A systematic approach to biomaterial device design is established.
  • The strategy facilitates the creation of complex, multifunctional devices.
  • Accelerated design and translation pathways for personalized therapies are enabled.

Conclusions:

  • The proposed unit operations-based engineering strategy addresses the limitations of traditional design approaches.
  • This framework supports the development of advanced biomaterial devices for precision medicine.
  • The strategy is crucial for tailoring personalized therapies to individual patient needs.