Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Opioids and breathing.

T V Santiago, N H Edelman

    Journal of Applied Physiology (Bethesda, Md. : 1985)
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Opioid drugs and endogenous opioid peptides significantly impact breathing control. Research shows specific brain effects, tolerance in addiction, and opioid influence on neonatal breathing, suggesting a role in modulating respiratory responses.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sleep and sleep disorders in pregnancy.

    Annals of internal medicine·2001
    Same author

    CO(2)/H(+) chemoreception in the cat pre-Bötzinger complex in vivo.

    Journal of applied physiology (Bethesda, Md. : 1985)·2000
    Same author

    Hypoxic excitation in neurons cultured from the rostral ventrolateral medulla of the neonatal rat.

    Journal of applied physiology (Bethesda, Md. : 1985)·2000
    Same author

    Pre-Bötzinger complex functions as a central hypoxia chemosensor for respiration in vivo.

    Journal of neurophysiology·2000
    Same author

    Patterns of phrenic motor output evoked by chemical stimulation of neurons located in the pre-Bötzinger complex in vivo.

    Journal of neurophysiology·1999
    Same author

    Variable extrathoracic airflow obstruction and chronic laryngotracheitis in Gulf War veterans.

    Chest·1999
    Same journal

    Thoroughbred horses susceptible to Recurrent Exertional Rhabdomyolysis have elevated skeletal muscle mitochondrial capacities.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Change in Neutrophil-to-Lymphocyte Ratio after acute and chronic exercise: A Systematic Review and Meta-Analysis.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Ankylosing spondylitis and muscle sympathetic nerve activity: a case study.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Intracranial vasomotor and blood flow responses to light intensity aerobic exercise in young adults: a 4D flow MRI study.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Comparative assessments of the COSMED adaptive mixing chamber vs. breath-by-breath methods for oxygen uptake measurements in recreationally active adults.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    Same journal

    Can we assess exercise metabolism from skin? Metabolomic profiles in skin dialysate collected during exercise.

    Journal of applied physiology (Bethesda, Md. : 1985)·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Respiratory Physiology

    Background:

    • Opioid drugs and endogenous opioid peptides are known to affect physiological functions.
    • Their precise roles in respiratory control, particularly in different life stages and conditions, require further elucidation.

    Purpose of the Study:

    • To review recent advancements concerning the effects of opioids on breathing.
    • To explore the influence of endogenous opioid systems on respiratory regulation.

    Main Methods:

    • Review of current literature on opioid effects on the central nervous system (pons and medulla).
    • Analysis of studies investigating tolerance to respiratory responses in opioid addiction.
    • Examination of the role of endogenous opioids in neonatal breathing and various physiological/pathological states.

    Related Experiment Videos

  • Discussion on the utility and limitations of naloxone in studying endogenous opioid influences.

    • Main Results:

    • Opioids exert site-specific effects on respiratory centers in the pons and medulla.
    • Variable tolerance to respiratory effects is observed in addicted individuals and their offspring.
    • Endogenous opioids influence breathing in early neonatal life and under specific physiological and disease conditions.
    • Naloxone's use as a tool has limitations and potential problems.

    Conclusions:

    • A parallel exists between endogenous opioid roles in pain modulation and respiration, especially in adults.
    • Endogenous opioids likely modulate responses to drugs and respiratory stimuli via inhibitory pathways.
    • Further research is needed to define specific opioid receptor and ligand effects on breathing control.