The anti-inflammatory action of maropitant in a mouse model of acute pancreatitis

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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection

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Atsushi Tsukamoto1, Minami Ohgoda1, Nozomi Haruki1

  • 1Laboratory of Laboratory Animal Science, Azabu University, 1-17-71 Fuchinobe, Chuou-ku, Sagamihara, Kanagawa 252-5201, Japan.

The Journal of Veterinary Medical Science
|January 19, 2018
PubMed

Insights

Maropitant, an NK1R antagonist, demonstrated anti-inflammatory effects in a mouse model of acute pancreatitis (AP). It reduced key inflammatory markers and cell infiltration, suggesting therapeutic potential beyond its antiemetic use.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Immunology

Background:

  • The neurokinin 1 receptor (NK1R) is implicated in the pathogenesis of acute pancreatitis (AP).
  • Maropitant is an established NK1R antagonist used as an antiemetic in veterinary medicine.

Purpose of the Study:

  • To investigate the anti-inflammatory effects of maropitant in a mouse model of acute pancreatitis.
  • To evaluate maropitant's impact on inflammatory markers and pancreatic tissue.

Main Methods:

  • Acute pancreatitis was induced in BALB/c mice using cerulein.
  • Maropitant was administered subcutaneously at 8 mg/kg.
  • Assessed NK1R and substance P (SP) mRNA expression, plasma amylase, lipase, IL-6 levels, and MPO staining for inflammatory cell infiltration.

Main Results:

  • Cerulein-induced AP elevated SP mRNA expression in pancreatic tissue.
  • Maropitant treatment significantly reduced plasma amylase and IL-6 levels.
  • Maropitant inhibited MPO-positive inflammatory cell infiltration in the pancreas.

Conclusions:

  • Maropitant exhibits significant anti-inflammatory activity in a mouse model of acute pancreatitis.
  • These findings suggest maropitant may have therapeutic applications in managing AP, complementing its antiemetic properties.
Keywords:
antiemeticinflammatory diseaseneurokinin 1 receptorpancreassubstance P

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