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The phosphatase PPM1A controls monocyte-to-macrophage differentiation

Samuel R Smith1, Kaitlyn Schaaf1, Nusrah Rajabalee2

  • 1Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Scientific Reports
|January 19, 2018
PubMed
Summary

Protein Phosphatase 1A (PPM1A) regulates how monocytes become macrophages. Overexpressing PPM1A slows differentiation, while reducing it speeds up the process, impacting host defense and inflammation.

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