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Anti-interleukin and interleukin therapies for psoriasis: current evidence and clinical usefulness

Ya-Chu Tsai1, Tsen-Fang Tsai2

  • 1Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Therapeutic Advances in Musculoskeletal Disease
|January 19, 2018
PubMed

Anti-interleukin (IL) therapies have emerged as a major treatment for patients with moderate-to-severe psoriasis. This article reviews the up-to-date results of pivotal clinical trials targeting the interleukins used for the treatment of psoriasis, including IL-1, IL-2, IL-6, IL-8, IL-10, IL-12, IL-17, IL-20, IL-22, IL-23, IL-36 and bispecific biologics IL-17A/tumor necrosis factor alpha (TNF-α). Cytokines involved in the circuits of psoriasis inflammation without ongoing clinical trials are also mentioned (IL-9, IL-13, IL-15, IL-16, IL-18, IL-19, IL-21, IL-24, IL-27, IL-33, IL-35, IL-37, and IL-38).

Keywords:
anti-interleukin therapybiologic agentsinterleukinpsoriasis

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