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Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.8K

Potential functions and implications of circular RNA in gastrointestinal cancer

Xiaoxia Ren1, Yongxing Du1, Lei You1

  • 1Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, P.R. China.

Oncology Letters
|January 19, 2018
PubMed

Insights

Circular RNAs (circRNAs) are key regulators of gene expression. This review explores their role in gastrointestinal cancer, highlighting their potential as diagnostic biomarkers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Circular RNAs (circRNAs) are endogenous non-coding RNAs with regulatory roles.
  • They influence gene expression at transcriptional and post-transcriptional levels.
  • circRNAs interact with microRNAs (miRNAs) and other molecules.

Purpose of the Study:

  • To provide an overview of circRNAs.
  • To elucidate the roles of circRNAs in gastrointestinal cancer development and progression.
  • To investigate circRNAs as potential diagnostic and predictive biomarkers for gastrointestinal cancer.

Main Methods:

  • Literature review of existing data on circRNAs.
  • Analysis of circRNA involvement in gastrointestinal cancer.
  • Evaluation of circRNAs for biomarker potential.

Main Results:

  • circRNAs are ubiquitously expressed in eukaryotic cells.
  • circRNAs play significant roles in biological processes.
  • circRNAs show promise as biomarkers for gastrointestinal cancer diagnosis and prediction.

Conclusions:

  • circRNAs are crucial in regulating gene expression.
  • circRNAs are implicated in gastrointestinal cancer pathogenesis.
  • circRNAs offer potential for novel diagnostic and therapeutic strategies in gastrointestinal cancer.
Keywords:
biomarkercircular RNAgastrointestinal cancermicroRNA sponge

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