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Updated: Feb 15, 2026
09:17
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
22.3K
Frontotemporal dementia: latest evidence and clinical implications
Juan Joseph Young1, Mallika Lavakumar1, Deena Tampi2
1Department of Psychiatry, MetroHealth Medical Center, Cleveland, OH, USA Case Western Reserve University, Cleveland, OH, USA.
Therapeutic Advances in Psychopharmacology
|January 19, 2018
Summary
Frontotemporal dementia (FTD) is a common cause of early-onset dementia. Recent advances reveal new diagnostic markers and potential treatments, though effective therapies are still under development.
Area of Science:
- Neuroscience
- Neurology
Background:
- Frontotemporal dementia (FTD) encompasses neurocognitive syndromes characterized by executive dysfunction, behavioral changes, and language deficits.
- FTD is the second leading cause of dementia in individuals under 65 and its prevalence is rising.
- Understanding FTD pathology, classification, assessment, and treatment is crucial.
Purpose of the Study:
- To review recent advancements in the understanding of FTD.
- To describe progress in neurobiological pathology, classification, assessment, and treatment of FTD.
Main Methods:
- A PubMed search was conducted for reviews and studies on FTD.
- Focus was placed on recent preclinical/clinical trials and systematic reviews.
- Key areas of investigation included genetics, neurobiology, neuroimaging, classification, and treatment.
Main Results:
- Significant progress has been made in understanding the molecular and neurobiological underpinnings of FTD variants.
- Genetic and histopathologic markers have been identified in the last decade.
- Current treatments are limited; nonpharmacological interventions show promise, and some medications may help specific symptoms, but no FTD-specific drugs are approved.
Conclusions:
- FTD is an underdiagnosed condition with diverse variants and distinct profiles.
- Emerging therapeutic targets show promise but require further validation.
- No FDA-approved treatments currently exist for FTD, necessitating continued research and development.
Keywords:
classificationfrontotemporal dementiafrontotemporal lobar degenerationgeneticsneurobiologytreatmentMore Related Videos
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